Highlands defeated the AmaKhosi on penalties after a 1-1 draw, and now face another one of South Africa’s giants in the form of Sundowns.
Coach Owen da Gama has spoken in the last few days of what a tough place Makhulong Stadium is for visiting teams, and he will hope his side can prove that again with the visit of the Brazilians.
The 2010 champions Bidvest Wits face a potentially tricky away day at Real Kings from the GladAfrica Championship, though they will fancy their chances of winning a semifinal spot.
Kings will be no pushovers, but Wits coach Gavin Hunt will expect his star-studded squad to be too strong for the second-tier side.
There is also a Limpopo Derby as Black Leopards travel to Baroka FC, a clash between two sides at the wrong end of the Premiership table.
Ironically, the teams will meet in Polokwane the week before in a league clash, while Leopards won on their last visit to Baroka in January 2019.
The last of the quarterfinals see second-tier TS Sporting host Bloemfontein Celtic.
The ties will be played on the weekend of March 14-15, with the exact dates, venues and kick-off times to be revealed by the Premier Soccer League at a later stage.
TS Sporting v Bloemfontein Celtic
Baroka FC v Black Leopards
Real Kings v Bidvest Wits
Highlands Park v Mamelodi Sundowns
In partnership with ANA and Sports Leo