The final opportunity of the opening stanza came to Anukani whose distant low drive missed the target as the two teams returned to the dressing rooms for the mandatory halftime recess.
Upon restart of play for the second half, Vipers called off Bob Olwoch for Allan Kayiwa and rested Siraje Sentamu for Paul Mucureezi in the double substitution.
On the 50th minute mark, Karisa headed over in the goal face off a Galiwango cross from the left.
On the hour mark, Vipers introduced Abdul-Karim Watambala for Bright Anukani.
Two minutes later, Emma Mukisa was rested for Aka Manikas in Kataka’s other change.
The second goal for the home side came in the 65th minute from impressive substitute Kayiwa who struck with the first time shot from 25 yards after a corner kick from Watambala.
Najib Yiga paved the way for Ceaser Lobi Manzoki for the final 23 minutes.
Sentamu shot straight toward Kasibante inside the area as Vipers plotted for more goals.
Five minutes ahead, Sentamu headed over an inviting free-kick from Bobosi Byaruhanga.
The final 10 minutes of the game witnessed three changes; two for Kataka and one for hosts.
Dread-locked forward Dan Muzeyi Sserunkuma replaced Karisa for Vipers.
Derrick Mawanje and Shakuru Mafabi came on for Swamadur Okur and Raymond Onyai respectively for Kataka.
Kataka captain Francis Odongo was cautioned for a late challenge on Watambala as Vipers won a free-kick near the goal area.
Mucureezi’s resultant free-kick was pushed out for a corner kick by goalkeeper Kasibante.
Mucureezi brushed from the near post off an inviting corner kick from Galiwango for the third goal, the icing on the cake.
Meanwhile, the round of 16 continues on Sunday, 20th March 2022 with two matches.
Police entertain third-tier side Mbale Heroes at the MTN Omondi Stadium, Lugogo in Kampala city.
At the Kakyeka Stadium in Mbarara city, Uganda Premier League entity Mbarara City shall take on Eastern regional side Iganga Young.
The winner of the Uganda Cup earns a ticket to represent the country at the CAF Confederation Cup.
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